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Title 

Evaluation of immunotoxicity of shizukaol B isolated from Chloranthus japonicus

Authors 

S W KwonYoung Kook KimJ Y KimH S RyuH K LeeJong Soon KangHwan Mook KimJ T HongY KimS B Han

Publisher 

Korean Society of Applied Pharmacology

Issue Date 

2011

Citation 

Biomolecules & Therapeutics, vol. 19, no. 1, pp. 59-64

Keywords 

B cellsChloranthus japonicusCytotoxicityImmunosuppressionShizukaol B

Abstract 

Dimeric sesquiterpenoid shizukaol B (SKB) was isolated from Chloranthus japonicus Sieb. Except that SKB inhibited adhesion molecule expression in monocytes and endothelial cells, no more biological and pharmacological activity of SKB had been reported until now. In this study, we examined immunosuppressive activity of SKB. SKB strongly inhibited lipopolysaccharide (LPS)- induced B cell proliferation with IC50 of 137 ng/ml, but slightly or not concanavalin A-induced T cell proliferation, LPS-induced macrophage NO production, and LPS-induced dendritic cell maturation. As a mechanism, SKB strongly induced apoptotic death of B cells, but not other cell types. These results suggested that SKB induced toxicity-mediated immunosuppression against B cells.

ISSN 

1976-9148

Link 

http://dx.doi.org/10.4062/biomolther.2011.19.1.059

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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