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Title | Anti-inflammatory diterpene from Thyrsanthera suborbicularis |
Authors | P Khiev; Sei Ryang Oh; Hee Sung Chae; Ok-Kyoung Kwon; Kyung Seop Ahn; Y W Chin; Hyeong Kyu Lee |
Publisher | Pharmaceutical Society of Japan |
Issue Date | 2011 |
Citation | Chemical & Pharmaceutical Bulletin, vol. 59, no. 3, pp. 382-384 |
Keywords | Euphorbiaceae; Inducible nitric oxide synthase; Nitric oxide; Rosane diterpenoid; Thyrsanthera suborbicularis |
Abstract | Bioactivity-guided isolation on a n-hexane-soluble fraction of Thyrsanthera suborbicularis led to the isolation of a new rosane-type diterpene, 19-hydroxy-1(10), 15-rosadiene (1), along with three known compounds, taraxerol, acetyl aleuritolic acid, and spathulenol. The structures of isolated compounds were determined by interpretation of NMR spectroscopic data and mass spectrometry. Compound 1 demonstrated significantly inhibitory activity on nitric oxide production in RAW264.7 lipopolysaccharide (LPS)-activated mouse macrophages with an IC50 value of 2.91 μg/ml via the suppression of inducible nitric oxide synthase (iNOS) mRNA expression. |
ISSN | 0009-2363 |
Link | |
Appears in Collections | |
Registered Date |
2017-04-19 |
| Files in This Item: | Size | Format | |
|---|---|---|---|
| 9731.pdf | 577Kb | Adobe PDF | 
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