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Title 

Anti-inflammatory diterpene from Thyrsanthera suborbicularis

Authors 

P KhievSei Ryang OhHee Sung ChaeOk-Kyoung KwonKyung Seop AhnY W ChinHyeong Kyu Lee

Publisher 

Pharmaceutical Society of Japan

Issue Date 

2011

Citation 

Chemical & Pharmaceutical Bulletin, vol. 59, no. 3, pp. 382-384

Keywords 

EuphorbiaceaeInducible nitric oxide synthaseNitric oxideRosane diterpenoidThyrsanthera suborbicularis

Abstract 

Bioactivity-guided isolation on a n-hexane-soluble fraction of Thyrsanthera suborbicularis led to the isolation of a new rosane-type diterpene, 19-hydroxy-1(10), 15-rosadiene (1), along with three known compounds, taraxerol, acetyl aleuritolic acid, and spathulenol. The structures of isolated compounds were determined by interpretation of NMR spectroscopic data and mass spectrometry. Compound 1 demonstrated significantly inhibitory activity on nitric oxide production in RAW264.7 lipopolysaccharide (LPS)-activated mouse macrophages with an IC50 value of 2.91 μg/ml via the suppression of inducible nitric oxide synthase (iNOS) mRNA expression.

ISSN 

0009-2363

Link 

http://dx.doi.org/10.1248/cpb.59.382

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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