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Title 

Phellinstatin, a new inhibitor of enoyl-ACP reductase produced by the medicinal fungus Phellinus linteus

Authors 

J W ChoYun-Ju KwonMi Jin SohnS J SeokWon Gon Kim

Publisher 

Elsevier

Issue Date 

2011

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 21, no. 6, pp. 1716-1718

Keywords 

AntibacterialEnoyl-ACP reductaseHispidinInhibitorPhellinus linteusStaphylococcus aureus

Abstract 

A new trimeric hispidin derivative, phellinstatin, was isolated from a culture broth of the medicinal fungus Phellinus linteus and its structure was established by various spectral analysis. Phellinstatin strongly inhibited Staphylococcus aureus enoyl-ACP reductase with an IC50 of 6 μM and also showed antibacterial activity against S. aureus and MRSA.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2011.01.080

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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