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Title 

TOX regulates the differentiation of human natural killer cells from hematopoietic stem cells in vitro

Authors 

So Hyun yoonS H LeeSuk Ran YoonM S KimZ H PiaoP K MyungTae-Don KimHai Young JungIn Pyo Choi

Publisher 

Elsevier

Issue Date 

2011

Citation 

Immunology Letters, vol. 136, no. 1, pp. 29-36

Keywords 

DifferentiationHigh-mobility group protein TOXNatural killer cellT-bet

Abstract 

Natural killer (NK) cells act important roles in innate immunity and adaptive immunity. However, the mechanisms governing NK cell development have not been clearly elucidated. Previous studies have shown that an HMG (high-mobility group) protein, TOX, is important for regulating the differentiation program of developing T cells in mice. In this study, we examined the role of TOX in differentiation of human NK cells. Knockdown of TOX in differentiating cells decreased the NK cell population identified by expression of NK surface markers and receptors. In addition, over-expression of TOX enhanced the differentiation of NK cells which give rise to a population showing effector functions of mature NK cells. Moreover, TOX influenced expression of T-bet (T-box expressed in T cells, also as known as Tbx21) during NK cell development. Overall, these results suggest that TOX is required for IL-15-mediated NK cell differentiation and affected expression of T-bet that plays critical roles in NK differentiation and maturation.

ISSN 

0165-2478

Link 

http://dx.doi.org/10.1016/j.imlet.2010.11.008

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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