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Title 

Phenolic compounds isolated from Zingiber officinale roots inhibit cell adhesion

 

건강으로부터 분리된 페놀릭 화합물의 세포접착 저해활성

Authors 

Seung Woong LeeJ H LimM S KimJ H JeongG Y SongWoo Song LeeMun Chual Rho

Publisher 

Elsevier

Issue Date 

2011

Citation 

Food Chemistry, vol. 128, no. 3, pp. 778-782

Keywords 

Cell adhesion moleculesGingerolsShogaolsTHP-1 cellsZingiber officinaleZingiberaceae

Abstract 

Inhibitors of cell adhesion molecule-mediated cell adhesion might be novel therapeutic agents for the treatment of various inflammatory diseases. In this study, nine phenolic compounds were isolated from the methanol extracts of Zingiber officinale roots by bioactivity-guided fractionation. The structures of the compounds were determined by spectroscopic analysis (1H, 13C NMR and MS), to be 6-gingerol (1), 8-gingerol (2), 10-gingerol (3), 6-shogaol (4), 8-shogaol (5), 10-shogaol (6), dehydro-6-gingerdione (7), dehydro-10-gingerdione (8) and 6-paradol (9). Compounds 3, 4, 5 and 7 inhibited direct binding between sICAM-1 and LFA-1 of the THP-1 cells in a dose-dependent manner with IC50 values of 57.6, 27.1, 65.4 and 62.0 μM, respectively. Compounds 4 and 7 had an inhibitory effect on direct binding between sVCAM-1 and VLA-4 of THP-1 cells. These results suggest that the phenolic compounds from Z. officinale roots are good candidates for therapeutic strategies aimed at inflammation.

ISSN 

0308-8146

Link 

http://dx.doi.org/10.1016/j.foodchem.2011.03.095

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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