상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Protein expression analysis in hematopoietic stem cells during osteopontin-induced differentiation of natural killer cells

Authors 

M S KimK S BaeH J KimSuk Ran YoonDoo-Byoung OhK W HwangW J JunS I ShimK D KimY W JungS Y ParkKi Sun KwonIn Pyo ChoiJ W Chung

Publisher 

Korean Society of Applied Pharmacology

Issue Date 

2011

Citation 

Biomolecules & Therapeutics, vol. 19, no. 2, pp. 206-210

Keywords 

Bcl-2ErkHematopoietic stem cellsNatural killer cellsOsteopontin

Abstract 

Natural Killer (NK) cells are the lymphocytes that are derived from hematopoietic stem cells, developed in the bone marrow from hematopoietic stem cells (HSC) by sequential acquisition of functional surface receptors, and express the repertoire of inhibitory and activating receptors. Recently, Osteopontin (OPN) has been identifi ed as a critical factor for differentiation of natural killer cells. However, the detailed mechanism of OPN-induced NK differentiation has been still to be elucidated. Here, we determined the signaling pathway and possible receptor for OPN in NK differentiation. OPN induced expression of Bcl-2 and activation of Erk kinase. Inhibition of Erk pathway decreased the effect of OPN on NK differentiation. In addition, the expression of integrin α9 was signifi cantly increased by OPN during NK differentiation, suggesting the possible role of a major signaling molecule for OPN- induced NK differentiation.

ISSN 

1976-9148

Link 

http://dx.doi.org/10.4062/biomolther.2011.19.2.206

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)