상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Oxygen tension regulates NK cells differentiation from hematopoietic stem cells in vitro

Authors 

So Hyun YoonS H LeeSuk Ran YoonP K MyungIn Pyo Choi

Publisher 

Elsevier

Issue Date 

2011

Citation 

Immunology Letters, vol. 137, no. 1, pp. 70-77

Keywords 

DifferentiationHematopoietic stem cellsHypoxiaNK cellsTranscription factors

Abstract 

Natural killer (NK) cells are differentiated from hematopoietic stem cells (HSCs) which are located at the lowest end of an oxygen gradient within the bone marrow (BM). In this report, we investigated whether oxygen tension could affect NK cell differentiation from hematopoietic cells in vitro. We found that hypoxia led to an inhibition of differentiation in NK cells, and increased oxygen supply alleviated this inhibition and restored NK cell differentiation under hypoxic condition. Hypoxia-treated cells demonstrated reduced mRNA expression of transcription factors (TFs) that have important roles in NK cell differentiation, such as EOMES, T-bet, GATA-3 and ETS-1. Moreover, hypoxia-pretreated cells recovered mRNA expression of TFs when the oxygen tension was changed to normoxia. Our findings suggest that oxygen tension modulates in vitro differentiation of NK cells through the regulation of TF expression.

ISSN 

0165-2478

Link 

http://dx.doi.org/10.1016/j.imlet.2011.02.020

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)