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Title 

Src family kinase potentiates the activity of nicotinic acetylcholine receptor in rat autonomic ganglion innervating urinary bladder

Authors 

N H KimK S ParkS K ChaJ H YoonB I YehKyou Hoon HanI D Kong

Publisher 

Elsevier

Issue Date 

2011

Citation 

Neuroscience Letters, vol. 494, no. 3, pp. 190-195

Keywords 

Major pelvic gangliaNicotinic acetylcholine receptorSrc family kinase

Abstract 

Src family kinases (SFKs), one of the tyrosine kinase groups, are primary regulators of signal transductions that control cellular functions such as cell proliferation, differentiation, survival, metabolism, and other important roles of the cell. One of the crucial functions of SFKs is to regulate the activities of various neuronal channels. In this study, we investigated the modulatory action of SFK on nicotinic acetylcholine receptors (nAChRs) expressed in rat major pelvic ganglion (MPG) neurons innervating the urinary bladder. PP1 and PP2 (5μM), selective Src-kinase inhibitors, attenuated ACh-induced ionic currents and [Ca 2+] i transients in MPG neurons, whereas PP3, an inactive analogue, had no effect. Blocking the tyrosine kinase activity of Src kinase by pp60 c-src inhibitory peptide also reduced the ACh-induced currents. Conversely, sodium orthovanadate (200μM), a tyrosine phosphatase inhibitor, significantly augmented the ACh-induced currents. In the kinase assay, the activities of SFKs in MPG neurons were also inhibited by PP2, but not by PP3. These data suggests that SFKs may have a facilitative role on the synaptic transmission in rat pelvic autonomic ganglion.

ISSN 

0304-3940

Link 

http://dx.doi.org/10.1016/j.neulet.2011.03.009

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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