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Title 

Microbial production of farnesol (FOH): Current states and beyond

 

파네솔의 미생물학적 생산: 현 기술 상태 및 전망

Authors 

C WangJ Y KimEui Sung ChoiS W Kim

Publisher 

Elsevier

Issue Date 

2011

Citation 

Process Biochemistry, vol. 46, no. 6, pp. 1221-1229

Keywords 

FarnesolFPP synthaseMetabolic engineeringMicrobial productionPhosphatases

Abstract 

Farnesol (FOH) recently has been paid close attention because of its intrinsic properties as a cosmetic, pharmaceutical and industrial material. However, extraction from natural sources and chemical synthesis often suffer from the low yield and purity. Metabolic engineering of microorganisms for FOH production is an alternative way to meet the ever-growing demands. Several efforts have been done to make it possible to produce FOH from microorganisms including S. cerevisiae and E. coli. With developments of systems biology and synthetic biology, an optimal industrial microorganism can be expected to produce FOH cost-effectively. This review aims to give an update on the various facets of FOH synthesis pathway including the features of involved genes and enzymes, and recent progresses on FOH production. Combining traditional metabolic engineering with these new fascinating molecular, systems biology and synthetic biology tools will provide a better understanding of FOH biosynthesis and a great potential of microbial production

ISSN 

0032-9592

Link 

http://dx.doi.org/10.1016/j.procbio.2011.02.020

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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