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Title 

A FLT3-inhibitory constituent from the rhizomes of Anemarrhena asphodeloides

Authors 

S Y HanYoung Won Chin

Publisher 

Informa Healthcare

Issue Date 

2011

Citation 

Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 26, no. 3, pp. 445-448

Keywords 

ALKAnemarrhena asphodeloidesFLT3mangiferinxanthone

Abstract 

Bioactivity-guided investigation for the rhizomes of Anemarrhena asphodeloides using the Fms-like tyrosine kinase 3 (FLT3) inhibition assay led to the identification of an active xanthone, mangiferin. Mangiferin was found to inhibit activity of the FLT3 wild type and a mutated form of FLT3 with IC 50 values of 0.7 and 1.2μM, respectively. Furthermore, this compound was assessed with a small panel of select kinases anaplastic lymphoma kinase (ALK), insulin receptor, and epidermal growth factor receptor) and was also found to be active in ALK assay.

ISSN 

1475-6366

Link 

http://dx.doi.org/10.3109/14756366.2010.515215

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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