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Title 

PAUF promotes adhesiveness of pancreatic cancer cells by modulating focal adhesion kinase

Authors 

Y LeeSu Jin KimHye-Jin MinJi Yoon JoE H ParkSang Seok Koh

Publisher 

Korean Society of Medical Biochemistry

Issue Date 

2011

Citation 

Experimental and Molecular Medicine, vol. 43, no. 2, pp. 82-90

Keywords 

AdhesionAnoikisFAKPancreatic cancerPAUFSignaling

Abstract 

Pancreatic cancer is a notorious disease with a poor prognosis and low survival rates, which is due to limited advances in understanding of the molecular mechanism and inadequate development of effective treatment options over the decades. In previous studies, we demonstrated that a novel soluble protein named pancreatic adenocarcinoma up-regulated factor (PAUF) acts on tumor and immune cells and plays an important role in metastasis and progression of pancreatic cancer. Here we show that PAUF promotes adhesiveness of pancreatic cancer cells to various extracellular matrix (ECM). Our results further support a positive correlation of activation and expression of focal adhesion kinase (FAK), a key player in tumor cell metastasis and survival, with PAUF expression. PAUF-mediated adhesiveness was significantly attenuated upon blockade of the FAK pathway. Moreover, PAUF appeared to enhance resistance of pancreatic cancer cells to anoikis via modulation of FAK. Our results suggest that PAUF-mediated FAK activation plays an important role in pancreatic cancer progression.

ISSN 

1226-3613

Link 

http://dx.doi.org/10.3858/emm.2011.43.5.030

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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