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Title 

Anti-inflammatory activity of constituents from Glechoma hederacea var. longituba

Authors 

J KimS SongI LeeY KimIck-Dong YooIn Ja RyooK Bae

Publisher 

Elsevier

Issue Date 

2011

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 21, no. 11, pp. 3483-3487

Keywords 

COX-2Glechoma hederaceaInflammationiNOSNf-κBRosmarinic acid

Abstract 

Rosmarinic acid, its analogues, and a phenolic compound were obtained from G. hederacea var. longituba. There were two new compounds, methyl isoferuloyl-7-(3,4-dihydroxyphenyl) lactate (1) and benzyl-4′-hydroxy- benzoyl-3′-O-β-d-glucopyranoside (4), and four known compounds (2, 3, 5 and 6). The structures of these compounds were determined on the basis of spectroscopic methods. Each compound was tested by NF-κB luciferase assay and three rosmarinic acid analogues inhibited NF-κB production and the induction of COX-2 and iNOS mRNA in HepG2 cells.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2011.02.002

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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