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Title 

Anticomplement activity of compounds isolated from the roots of euphorbia kansui

Authors 

G LiJ H KimG ShenJ LeeHyeong Kyu LeeSei Ryang Oh

Publisher 

Korean Society of Applied Biological Chemistry

Issue Date 

2011

Citation 

Journal of Applied Biological Chemistry, vol. 54, no. 2, pp. 159-162

Keywords 

3-dimethylbutyryl)-13-o-n-dodecanoyl-13-hydroxyingenol3-o-(24'z-decadienoyl)- ingenolAnticomplement activityEuphorbia kansuiKansuiphorin cO-(2'e

Abstract 

The anticomplement activity-guided fractionation of the methanol extract of Euphorbia kansui L. resulted in isolation of three diterpenes, two triterpenes, and two sterols (1-7) from ethyl acetate fraction. By spectroscopic analysis, their chemical structures were elucidated as: β-amyrin (1); kansuiphorin C (2); 3-O-(2'E,4'Z-decadienoyl)-ingenol (3); 3-O-(2,3-dimethylbutyryl)-13-O-ndodecanoyl- 13-hydroxyingenol (4); β-sitosterol (5); α-euphol (6); β-sitosterol-3-O-β-Dglucopyranoside (7). These compounds were investigated in vitro for their anticomplement activity against the classical pathway of the complement system, with compounds 2-4 exhibiting significant anticomplement activity with respective 50% inhibitory concentration values of 44.1±3.8, 89.5±5.5, and 152.1±6.2 μM.

ISSN 

1229-2737

Link 

http://dx.doi.org/10.3839/jksabc.2011.026

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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