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Title 

A new xanthene from Desmostachya bipinnata (L.) stapf inhibits signal transducer and activator of transcription 3 (STAT3) and low-density lipoprotein-oxidation

Authors 

S ShresthaJ H ParkD Y LeeJ G ChoE CuiI S ChungByoung-Mog KwonM H ChoTae Sook JeongN I Baek

Publisher 

Korean Society of Applied Biological Chemistry

Issue Date 

2011

Citation 

Journal of Applied Biological Chemistry, vol. 54, no. 2, pp. 308-311

Keywords 

26-dihydroxy-7-methoxy-3h-xanthen-3-oneDesmostatchya bipinnataLow-density lipoprotein-oxidationSignal transducer and activator of transcription

Abstract 

A new xanthene was isolated from the methanolic extract of Desmostachya bipinnnata through repeated silica gel and octadecyl silica gel column chromatographies. Based on spectroscopic data including nuclear magnetic resonance, fast atom bombardment mass spectrometry, and infrared spectroscopy, chemical structure of the compound was determined to be 2,6-dihydroxy-7-methoxy-3H-xanthen-3-one. The compound exhibited inhibitions of signal transducer and activator of transcription 3-dependent luciferase activity in HCT-116 colon cancer cell line with IC50 value of 5 μM and low-density lipoprotein-oxidation with IC50 value of 27.2 μM.

ISSN 

1229-2737

Link 

http://dx.doi.org/10.3839/jksabc.2011.049

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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