상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

The conformation and CETP inhibitory activity of [10]-dehydrogingerdione isolated from Zingiber officinale

 

생강으로부터 분리한 [10]-데하이드로 진저다이온의 배좌와 CETP 저해활성

Authors 

S Y ChoiG S ParkSung Yoon LeeJi Yeon KimYoung Kook Kim

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2011

Citation 

Archives of Pharmacal Research, vol. 34, no. 5, pp. 727-731

Keywords 

Cholesteryl ester transfer proteinGingiber officinaleInhibitor

Abstract 

In the course of searching for cholesteryl ester transfer protein (CETP) inhibitors from natural sources, a new type of CETP inhibitor, [10]-dehydrogingerdione (1), was isolated from the extract of rhizomes of Zingiber officinale Roscoe. By NMR spectroscopic analysis of its (1)HNMR, (13)C-NMR, and (1)H-(1)H COSY, HMBC, HMQC and NOESY, more precise structure, compared with its originally proposed structures, of [10]-dehydrogingerdione has been elucidated. This active compound inhibited human plasma CETP with IC(50) values of 35 μM.

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/s12272-011-0505-5

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)