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Title 

Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy: Part I

Authors 

J S YangD SongB LeeW J KoS K ParkMi Sun WonK LeeH M KimG Han

Publisher 

Elsevier

Issue Date 

2011

Citation 

European Journal of Medicinal Chemistry, vol. 46, no. 7, pp. 2861-2866

Keywords 

Aliphatic amido-quaternary ammonium saltsGTPase RAt Sarcoma (Ras)NSC126188PerifosinePiperazine alkyl derivativesRhoB

Abstract 

We synthesized novel aliphatic amido-quaternary ammonium salts in an effort to discover anticancer agents that increase Ras homolog gene family, member B, (RhoB) levels. These compounds exert anti-proliferative activities against several human cancer cell types. Seventeen compounds, varying in aliphatic carbon chain length and N-substituents, were synthesized and their biological activities were evaluated. Of these 17 compounds, compound 3i emerged as the most promising anticancer compound by promoting apoptosis through the RhoB mediated pathway. Potent biological activities observed for these novel aliphatic amido-quaternary ammonium salt analogues support their potential as anticancer, chemotherapeutic agents.

ISSN 

0223-5234

Link 

http://dx.doi.org/10.1016/j.ejmech.2011.04.009

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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