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Title 

Steatosis induced by the accumulation of apolipoprotein A-I and elevated ROS levels in H-ras12V transgenic mice contributes to hepatic lesions

Authors 

A G WangH B MoonJ I ChaeJ M KimY E KimDae Yeul YuD S Lee

Publisher 

Elsevier

Issue Date 

2011

Citation 

Biochemical and Biophysical Research Communications, vol. 409, no. 3, pp. 532-538

Keywords 

Apolipoprotein A-IH-ras12VHepatic lesionsSteatosisTransgenic mice

Abstract 

Hepatic steatosis is considered to have an important impact on liver tumorigenesis, despite a lack of clear experimental evidence. Histopathological analysis of H-ras12V transgenic mice showed liver lesions on a steatosis background had significantly higher incidence than on a non-steatosis background. Further investigation showed that apolipoprotein A-I was elevated and accumulated around fatty vacuoles. This elevated level of apolipoprotein A-I was coupled with an elevated level of H-ras12V protein and ROS. In conclusion, our results suggest that the expression of H-ras12V oncogene leads to elevated levels of ROS and apolipoprotein A-I that contribute to steatosis. The steatosis, in turn, promotes the development of hepatic lesions induced by H-ras12V oncogene.

ISSN 

0006-291X

Link 

http://dx.doi.org/10.1016/j.bbrc.2011.05.039

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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