상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Silkworm hemolymph down-regulates the expression of endoplasmic reticulum chaperones under radiation-irradiation

Authors 

K R LeeS W KimY K KimK KwonJ S ChoiKweon YuO Y Kwon

Publisher 

MDPI AG

Issue Date 

2011

Citation 

International Journal of Molecular Sciences, vol. 12, no. 7, pp. 4456-4464

Keywords 

ChaperoneEndoplasmic reticulum (ER)Ischemia-responsive protein 94 (irp94)RadiationSilkworm hemolymph

Abstract 

We demonstrated that up-regulation of gene expression of endoplasmic reticulum (ER) chaperones (BiP, calnexin, calreticulin, ERp29) and ER membrane kinases (IRE1, PERK, ATF6) was induced by radiation in neuronal PC12 cells. However, addition of silkworm, Bombyx mori, hemolymph to irradiated cells resulted in an obvious decrease in expression of these genes, compared with a single radiation treatment. In contrast, one of the ER chaperones, "ischemia-responsive protein 94 kDa" (irp94), was up-regulated by radiation. However, addition of silkworm hemolymph resulted in no change in the expression of irp94, with an expression pattern that differed from that of ER chaperones. Based on these results, we propose that silkworm hemolymph contains factors that regulate a decrease in the expression of ER chaperones under radiation-irradiation conditions, with the exception of irp94, which is not down-regulated. We suggest that this difference in the molecular character of irp94 may provide a clue to the biological functions associated with ER stress pathways, particularly the effects of radiation.

ISSN 

1422-0067

Link 

http://dx.doi.org/10.3390/ijms12074456

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


Files in This Item: SizeFormat
10016.pdf451KbAdobe PDF
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)