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Title 

An autonomous CMOS hysteretic sensor for the detection of desorption-free DNA hybridization

Authors 

K H LeeS H ChoiJ O LeeMi Jin SohnJ B YoonG H Cho

Publisher 

Elsevier

Issue Date 

2011

Citation 

Biosensors & Bioelectronics, vol. 26, no. 11, pp. 4591-4595

Keywords 

CapacitanceDesorptionDNA hybridizationImpedanceSensor

Abstract 

This paper describes a sensor for label-free, fully electrical detection of DNA hybridization based on capacitive changes in the electrode-electrolyte interface. The sensor measures capacitive changes in real time according to a charging-discharging principle that is limited by the hysteresis window. In addition, a novel autonomous searching technique, which exclusively monitors desorption-free hybridized electrodes among electrode arrays, enhances the performance of the sensor compared with conventional capacitive measurement. The sensor system achieves a detection range of 80. dB. The integrated circuit sensor is fabricated with a 0.35 μm CMOS process. The proposed sensor offers rapid, robust and inexpensive measurement of capacitance with highly integrated detection circuitry. It also facilitates quantitative evaluations of molecular densities on a chip with distinctive impedance variations by monitoring desorption-free hybridized electrodes. Our electrical biosensor has great potential for use with bio analytical tools and point-of-care diagnosis.

ISSN 

0956-5663

Link 

http://dx.doi.org/10.1016/j.bios.2011.04.033

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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