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Title 

Uridine-based paramagnetic supramolecular nanoaggregate with high relaxivity capable of detecting primitive liver tumor lesions

Authors 

U BhuniyaH MoonH LeeK S HongS LeeDae Yeul YuJ S Kim

Publisher 

Elsevier

Issue Date 

2011

Citation 

Biomaterials, vol. 32, no. 27, pp. 6533-6540

Keywords 

ComplexationGadolinium Gd3+Magnetic resonance imaging (MRI)RelaxivityTransmetallationUridine

Abstract 

The water soluble uridine-based paramagnetic self-assembled amphiphilic molecules (LGd2-5) with DTTA binding site were synthesized and have been characterized in regard to their T1 magnetic resonance imaging (MRI) contrast agent (CA) properties. The water proton relaxivities have been measured in phosphate buffered saline (PBS) at 36 °C at 3 different magnetic fields. Among the self-assembled CAs, LGd3 showed unprecedented, high relaxivities of 30.3 and 23.4 mM-1 s-1 in PBS solution at 36 °C at 0.47 and 1.41 T, respectively. The non-covalent interactions between the new CAs and human serum albumin (HSA) have been investigated and the relaxivity was further increased by 135-215% depending on alkyl chain lengths. The chemically inertness of these complexes (LGd1, LGd2, LGd3, LGd4) against biologically most abundant metal ion (i.e. Zn2+) have shown within the range of commercial DTPA-based CAs. In vivo pharmacokinetics of the complex LGd3 showed highly specific for hepatocytes resulting in increase of contrast noise ratio by ∼240% in T1-weighted MR images of mouse liver 2 h after injection of the LGd3. It is capable to detect small hepatocellular carcinoma (HCC) with diameter of 1.5 mm.

ISSN 

0142-9613

Link 

http://dx.doi.org/10.1016/j.biomaterials.2011.05.054

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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