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Title 

Lipid-soluble ginseng extract induces apoptosis and G0/G1 cell cycle arrest in NCI-H460 human lung cancer cells

Authors 

M R KangH M KimJong Soon KangK LeeS D LeeD H HyunM J InS K ParkD C Kim

Publisher 

Springer Verlag (Germany)

Issue Date 

2011

Citation 

Plant Foods for Human Nutrition, vol. 66, no. 2, pp. 101-106

Keywords 

Apoptosis inductionCaspase activationG0/G1 phase arrestHuman lung cancer cellLipid-soluble ginseng extract

Abstract 

This study was performed to elucidate the anticancer mechanism of a lipid-soluble ginseng extract (LSGE) by analyzing induction of apoptosis and arrest of cell cycle progression using the NCI-H460 human lung cancer cell line. Proliferation of NCI-H460 cells was potently inhibited by LSGE in a dose-dependent manner. The cell cycle arrest at the G0/G1 phase in NCI-H460 cells was induced by LSGE. The percentage of G0/G1 phase cells significantly increased, while that of S phase cells decreased after treatment with LSGE. The expr.occurred through apoptosis, which was accompanied by increasing the activity of caspases including caspase-8, caspase-9 and caspase-3. Consistent with enhancement of caspase activity, LSGE increased protein levels of cleaved caspase-3, caspase-8, caspase-9, and poly-ADP-ribose polymerase (PARP). These apoptotic effects of LSGE were inhibited by the pan-caspase inhibitor Z-VAD-fmk. These findings indicate that LSGE inhibits NCI-H460 human lung cancer cell growth by cell cycle arrest at the G0/G1 phase and induction of caspase-mediated apoptosis.

ISSN 

0921-9668

Link 

http://dx.doi.org/10.1007/s11130-011-0232-6

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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