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Title 

Phenotypic and functional maturation of dendritic cells induced by polysaccharide isolated from Paecilomyces cicadae

Authors 

H S KimJ Y KimH S RyuB R ShinJong Soon KangH M KimY O KimJ T HongY KimS B Han

Publisher 

Mary Ann Liebert

Issue Date 

2011

Citation 

Journal of Medicinal Food, vol. 14, no. 7, pp. 847-856

Keywords 

dendritic cell maturationmitogen-activated protein kinasesnuclear factor-jBPaecilomyces cicadaeToll-like receptor 4

Abstract 

Paecilomyces cicadae Miquel Samson is the anamorph of Cordyceps cicadae Shing and is used in functional foods for the prevention and treatment of various diseases. In the present study, we examined the effects of P. cicadae polysaccharide (PCP) on dendritic cell (DC) maturation. Phenotypic maturation of DCs by PCP was confirmed by the elevated expressions of CD80, CD86, major histocompatibility complex (MHC)-I, and MHC-II molecules and functional maturation by increased expression of interleukin-12, interleukin-1β, and tumor necrosis factor-α, enhanced allogenic T cell stimulation, and decreased endocytosis. PCP induced the maturation of DCs from C3H/HeN and C57BL/6 mice but not from Toll-like receptor (tlr) 4-/- knockout mice and TLR4-mutated C3H/HeJ mice, which suggests that TLR4 is the membrane receptor for PCP. PCP increased the degradation of inhibitor of nuclear factor-κB (NF-κB) α/β, which enhanced the nuclear translocation of NF-κB p50/p65 and induced the phosphorylation of extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinases, which are signaling molecules downstream of TLR4. These results indicate that PCP induces DC maturation through TLR4 signaling.

ISSN 

1096-620X

Link 

http://dx.doi.org/10.1089/jmf.2011.1575

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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