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Title | Characteristic of alkylated chalcones from Angelica keiskei on influenza virus neuraminidase inhibition |
| 신선초로부터 분리한 알킬레이트 칼콘의 인플루엔자 바이러스 뉴라미니데이즈 저해 활성 |
Authors | Ji Young Park; Hyung Jae Jung; Young Min Kim; Su-Jin Park; Mun Chual Rho; K H Park; Young Bae Ryu; Woo Song Lee |
Publisher | Elsevier |
Issue Date | 2011 |
Citation | Bioorganic & Medicinal Chemistry Letters, vol. 21, no. 18, pp. 5602-5604 |
Keywords | Alkylated chalcone; Angelica keiskei; H1N1; Neuraminidase |
Abstract | As part of our ongoing effort to develop influenza virus neuraminidase (NA) inhibitors from various medicinal plants, we utilized bioassay-guided fractionation to isolated six alkylated chalcones (1-6) from Angelica keiskei. Xanthokeistal A (1) emerged as new compound containing the rare alkyl substitution, 6,6-dimethoxy-3-methylhex-2-enyl. When we tested the ability of these individual alkyl substituted chalcones to inhibit influenza virus NA hydrolysis, we found that 2-hydroxy-3-methyl-3-butenyl alkyl (HMB) substituted chalcone (3, IC50 = 12.3 μM) showed most potent inhibitory activity. The order of potency of substituted alkyl groups on for NA inhibition was HMB >6-hydroxyl-3,7-dimethyl-octa-2,7-dienyl > dimethylallyl > geranyl. All NA inhibitors screened were found to be reversible noncompetitive inhibitors. |
ISSN | 0960-895X |
Link | |
Appears in Collections | |
Registered Date |
2017-04-19 |
