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Title 

Small-molecule-based nanoassemblies as inducible nanoprobes for monitoring dynamic molecular interactions inside live cells

Authors 

S LeeK H LeeJ S HaSeung Goo LeeT K Kim

Publisher 

Wiley-Blackwell

Issue Date 

2011

Citation 

Angewandte Chemie International Edition, vol. 50, no. 37, pp. 8709-8713

Keywords 

fluorescencemolecular interactionsnanoassembliesnanoparticlesproteins

Abstract 

Seeing into cells: Genetically engineered, labeled ferritin is used to form biological nanoparticles displaying bait (B) and prey (P) molecules inside cells (see picture). Specific bait-prey interactions induce the interconnected assembly of nanoparticles into nanoclusters on a timescale of seconds. This phenotypic readout with a small molecule as an inducible switch was used to directly visualize dynamic molecular interactions within living cells.

ISSN 

1433-7851

Link 

http://dx.doi.org/10.1002/anie.201101467

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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