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Title 

Biosynthesis of plant-specific phenylpropanoids by construction of an artificial biosynthetic pathway in Escherichia coli

 

대장균에서 페닐프로판노이드 인공 생합성

Authors 

Oksik ChoiC Z WuSun-Young KangJong Seog AhnT B UhmYoung-Soo Hong

Publisher 

Springer

Issue Date 

2011

Citation 

Journal of Industrial Microbiology (& Biotechnology), vol. 38, no. 10, pp. 1657-1665

Abstract 

Biological synthesis of plant secondary metabolites has attracted increasing attention due to their proven or assumed beneficial properties and health-promoting effects. Phenylpropanoids are the precursors to a range of important plant metabolites such as the secondary metabolites belonging to the flavonoid/stilbenoid class of compounds. In this study, engineered Escherichia coli containing artificial phenylpropanoid biosynthetic pathways utilizing tyrosine as the initial precursor were established for production of plant-specific metabolites such as ferulic acid, naringenin, and resveratrol. The construction of the artificial pathway utilized tyrosine ammonia lyase and 4-coumarate 3-hydroxylase from Saccharothrix espanaensis, cinnamate/4-coumarate:coenzyme A ligase from Streptomyces coelicolor, caffeic acid O-methyltransferase and chalcone synthase from Arabidopsis thaliana, and stilbene synthase from Arachis hypogaea.

ISSN 

0169-4146

Link 

http://dx.doi.org/10.1007/s10295-011-0954-3

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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