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Title 

Inhibitory effects on nuclear factor jB of the Vietnamese freshwater cyanobacteria

Authors 

T D NguyenT T DuongT P Q LeV M ChauM H LeD K DangJung Joon LeeM L Bourguet-Kondracki

Publisher 

Springer Verlag (Germany)

Issue Date 

2011

Citation 

Medicinal Chemistry Research, vol. 20, no. 6, pp. 790-793

Keywords 

Anabaena spCyanobacteriaCytotoxicityMicrocystis aeruginosaNF-κB

Abstract 

Several Vietnamese freshwater cyanobacteria were collected and evaluated for their effects on the transcriptional nuclear factor κB (NF-κB) which are involving in the cancer and inflammatory diseases. Five extraction conditions were tested and a solution of 2% acetic acid in methanol provided highest yield of extract from bacterial biomass. The Microcystis aeruginosa TC-1 and TC-3 strains showed strong NF-κB inhibitory activity with IC 50 values of 6.1 and 5.3 μg/ml, respectively. Moreover, all tested cyanobacteriaexhibited cytotoxicity on human cervical cancer HeLa cells in a dose-dependent manner. Ergosterol (1) isolated from M. aeruginosa TC-3 strains strongly inhibited NF-κB activation with IC50 values of 0.91 μg/ml.

ISSN 

1054-2523

Link 

http://dx.doi.org/10.1007/s00044-010-9409-z

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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