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Title 

Gene silencing by siRNA microhydrogels via polymeric nanoscale condensation

Authors 

C A HongS H LeeJ S KimJ W ParkK H BaeHye Jung MokT G ParkH Lee

Publisher 

American Chemical Society

Issue Date 

2011

Citation 

Journal of American Chemical Society, vol. 133, no. 35, pp. 13914-13917

Abstract 

The first attempt to prepare biologically active siRNA-based microhydrogels is reported. The self-assembled microhydrogels were fabricated using sense/antisense complementary hybridization between single-stranded linear and Y-shaped trimeric siRNAs. The siRNA microhydrogels were condensed using a popular cationic polymer such as LPEI to form compact, stable siRNA/polymeric nanoparticles that exhibited superb cellular uptake efficiency and gene silencing activity.

ISSN 

0002-7863

Link 

http://dx.doi.org/10.1021/ja2056984

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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