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Title 

The endogenous siRNA pathway in Drosophila impacts stress resistance and lifespan by regulating metabolic homeostasis

Authors 

D H LimC T OhL LeeJ S HongS H NohSeungwoo HwangS KimS J HanY S Lee

Publisher 

Elsevier

Issue Date 

2011

Citation 

FEBS Letters, vol. 585, no. 19, pp. 3079-3085

Keywords 

Dicer-2DrosophilaEndogenous siRNALifespanMetabolic homeostasisStress response

Abstract 

Small non-coding RNAs regulate gene expression in a sequence-specific manner. In Drosophila, Dicer-2 (Dcr-2) functions in the biogenesis of endogenous small interfering RNAs (endo-siRNAs). We identified 21 distinct proteins that exhibited a ≥1.5-fold change as a consequence of loss of dcr-2 function. Most of these were metabolic genes implicated in stress resistance and aging. dcr-2 Mutants had reduced lifespan and were hypersensitive to oxidative, endoplasmic reticulum, starvation, and cold stresses. Furthermore, loss of dcr-2 function led to abnormal lipid and carbohydrate metabolism. Our results suggest roles for the endo-siRNA pathway in metabolic regulation and defense against stress and aging in Drosophila.

ISSN 

0014-5793

Link 

http://dx.doi.org/10.1016/j.febslet.2011.08.034

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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