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Title 

Synthesis and anti-platelet activity of obovatol derivatives

Authors 

J H KwakS LeeE S ParkJ K InJ SongY J KimN S ChoiH LeeY P YunJ T HongYoung Shin KwakK H MinJ K Jung

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2011

Citation 

Archives of Pharmacal Research, vol. 34, no. 7, pp. 1107-1112

Keywords 

Anti-platelet activityDerivativesObovatolSmall molecules

Abstract 

Obovatol derivatives were synthesized and evaluated for anti-platelet activity. Three derivatives (1, 2, 4i) displayed equipotent activity to obovatolin arachidonic acid-induced platelet aggregation. An initial SAR study revealed that the introduction of alkoxy group in B ring could enhance inhibitory activity.

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/s12272-011-0708-9

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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