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Title 

Long-term adaptation of global transcription and metabolism in the liver of high-fat diet-fed C57BL/6J mice

Authors 

G M DoHea-Young OhE Y KwonY Y ChoS K ShinH J ParkS M JeonE KimCheol-Goo HurT S ParkM K SungR A McGregorM S Choi

Publisher 

Wiley-Blackwell

Issue Date 

2011

Citation 

Molecular Nutrition & Food Research, vol. 55, no. S2, pp. S173-S185

Keywords 

Diet-induced obesityInsulin resistanceMetabolic profileMicroarrayTranscriptional response

Abstract 

This study investigated the global transcriptional and metabolic changes occurring at multiple time points over 24wk in response to a high-fat diet (HFD). Methods and results: C57BL/6J mice were fed a HFD or normal diet (ND) over 24 wk. HFD-fed mice developed early clinical indicators of obesity-related co-morbidities including fatty liver, insulin resistance, hyperglycemia and hypercholesterolemia. Time-course microarray analysis at eight time points over 24 wk identified 332 HFD responsive genes as potential targets to counteract diet-induced obesity (DIO) and related co-morbidities. Glucose regulating enzyme activity and gene expression were altered early in the HFD-fed mice. Fatty acid (FA) and triglyceride (TG) accumulation in combination with inflammatory changes appear to be likely candidates contributing to hepatic insulin resistance. Cidea seemed to be one of representative genes related to these changes. Conclusion: Global transcriptional and metabolic profiling across multiple time points in liver revealed potential targets for nutritional interventions to reverse DIO. In future, new approaches targeting HFD responsive genes and hepatic metabolism could help ameliorate the deleterious effects of an HFD and DIO-related complication.

ISSN 

1613-4125

Link 

http://dx.doi.org/10.1002/mnfr.201100064

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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