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Title 

Synthesis of 2,4,6-tripyridyl pyridines, and evaluation of their antitumor cytotoxicity, topoisomerase I and II inhibitory activity, and structure-activity relationship

 

삼중피리딘 화합물의 항암효과, topoisomerase 활성 억제 효과, 구조 활성 관계

Authors 

B S JeongH ChoiYoung Shin KwakE S Lee

Publisher 

The Korean Chemical Society

Issue Date 

2011

Citation 

Bulletin of the Korean Chemical Society, vol. 32, no. 10, pp. 3566-3570

Keywords 

2,4,6-Tripyridyl pyridineCytotoxicitySAR studyTerpyridineTopoisomerase inhibition

Abstract 

A series of 2,4,6-tripyridyl pyridines were synthesized, and evaluated for their antitumor cytotoxicity, topoisomerase I and II inhibitory activity. From the eighteen prepared compounds, compounds 10-12 have shown better or similar cytotoxicity against several human cancer cell lines as compared to 2,2':6',2''- terpyridine and doxorubicin. Especially, compound 10 exhibited the most potent cytotoxicity better than positive controls. Structure-activity relationship study indicated that 2,2':6',2''-terpyridine skeleton has an important role in displaying significant cytotoxicity against several human cancer cell lines.

ISSN 

0253-2964

Link 

http://dx.doi.org/10.5012/bkcs.2011.32.10.3566

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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