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Title 

IL-22 producing NKp46+ innate lymphoid cells can differentiate from hematopoietic precursor cells

 

조혈줄기세포로부터 IL-22를 생산하는 innate lymphoid cell의 분화

Authors 

M S KimWon Sam KimZ H PiaoSohyun YunS H LeeSu Ui LeeM JeongH N SunYoung-Jun ParkHaiyoung JungSuk Ran YoonIn Pyo Choi

Publisher 

Elsevier

Issue Date 

2011

Citation 

Immunology Letters, vol. 141, no. 1, pp. 61-67

Keywords 

DifferentiationIL-22NCR22NK cellsRORγt

Abstract 

The IL-22 NKp46+ innate lymphoid cells, NCR22 cells, are very important for the early host defense against microbial pathogens. We show here that NCR22 cells were differentiated from Lin-CD127+CD117+ cells that were derived from hematopoietic precursor cells (HPCs) of mouse bone marrow cells. The combination of low concentrations of IL-23 and IL-15 induced differentiation of NCR22 cells from Lin-CD127+CD117+ cells. NCR22 cells expressed a large amount of IL-22 and RORγt, and they had poor cytolytic activity and produced little IFN-γ Lin-CD127+CD117+ cells were very similar to intestinal lamina propria LTi-like cells; both cells dominantly expressed RORγt and IL-22. Meanwhile, Lin-CD127-CD117+ cells that were also derived from HPCs did not express RORγt and IL-22, and they developed into conventional NK cells, not into NCR22 cells. These findings revealed that NCR22 cells can be differentiated from Lin-CD127+CD117+ cells which are derived from HPCs.

ISSN 

0165-2478

Link 

http://dx.doi.org/10.1016/j.imlet.2011.07.007

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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