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Title 

Self-assembled peptidic architecture with a tooth shape: folding into shape

Authors 

S KwonH S ShinJ GongJ H EomA JeonS H YooIm Sik ChungS J ChoH S Lee

Publisher 

American Chemical Society

Issue Date 

2011

Citation 

Journal of American Chemical Society, vol. 133, no. 44, pp. 17618-17621

Abstract 

Molecular self-assembly is the spontaneous association of molecules into structured aggregates by which nature builds complex functional systems. While numerous examples have focused on 2D self-assembly to understand the underlying mechanism and mimic this process to create artificial nano- and microstructures, limited progress has been made toward 3D self-assembly on the molecular level. Here we show that a helical β-peptide foldamer, an artificial protein fragment, with well-defined secondary structure self-assembles to form an unprecedented 3D molecular architecture with a molar tooth shape in a controlled manner in aqueous solution. Powder X-ray diffraction analysis, combined with global optimization and Rietveld refinement, allowed us to propose its molecular arrangement. We found that four individual left-handed helical monomers constitute a right-handed superhelix in a unit cell of the assembly, similar to that found in the supercoiled structure of collagen.

ISSN 

0002-7863

Link 

http://dx.doi.org/10.1021/ja2082476

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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