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Title 

Neuron-specific expression of Scratch genes during early zebrafish development

 

제브라퓌쉬 발생중 Scratch 유전자들의 신경특이적 발현

Authors 

T M T DamH T KimH Y MoonK S HwangY M JeongK H YouJeong Soo LeeC H Kim

Publisher 

Springer Verlag (Germany)

Issue Date 

2011

Citation 

Molecules and Cells, vol. 31, no. 5, pp. 471-475

Keywords 

Central nervous systemNeuronal differentiationScratchZebrafish

Abstract 

Scratch (scrt) genes are neural-specific in mammals, but their homologues have not been well studied in nonmammalian vertebrates. In this report, we isolated three zebrafish scrt genes, scratch1a (scrt1a), scratch1b (scrt1b), and scratch2 (scrt2), which belong to the Snail superfamily of zinc finger transcription factors. Spatiotemporal expression analysis revealed that scrt1a and scrt2 were initially detected in the central nervous system (CNS) during early somitogenesis while scrt1b was first detectable in neuronal clusters in the brain during late somitogenesis. Interestingly, scrt-expressing cells largely overlapped with huC-positive differentiating neurons and partially with neurogenin1-positive neuronal precursor cells. In addition, scrt-expressing cells were dramatically increased in mind bomb, a neurogenic mutant. Taken together, these results suggest that each zebrafish scrt gene is specifically expressed in neuronal cells and may be involved in differentiation of distinct neuronal populations in the vertebrate nervous system.

ISSN 

1016-8478

Link 

http://dx.doi.org/10.1007/s10059-011-0052-4

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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