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Title 

Lidocaine induces endoplasmic reticulum stress-associated apoptosis in Vitro and in Vivo

Authors 

D Y HongK KwonK R LeeY J ChoiT W GooKweon YuS W KimO Y Kwon

Publisher 

MDPI AG

Issue Date 

2011

Citation 

International Journal of Molecular Sciences, vol. 12, no. 11, pp. 7652-7661

Keywords 

ApoptosisEndoplasmic reticulum (ER) stressER chaperoneER stress sensorLidocaine

Abstract 

We demonstrated that upregulation of both gene expression of endoplasmic reticulum (ER) stress chaperones (BiP, calnexin, calreticulin, and PDI) and ER stress sensors (ATF6, IRE1 and PERK) was induced by lidocaine, a local anesthetic, in PC12 cells. In addition to gene regulation, lidocaine also induced typical ER stress phenomena such as ART6 proteolytic cleavage, eIF2 alpha phosphorylation, and XBP1 mRNA splicing. In in vivo experiments, while lidocaine downregulated gene expression of anti-apoptotic factors (Bcl-2 and Bcl-xl), pro-apoptotic factor (Bak and Bax) gene expression was upregulated. Furthermore, lidocaine induced apoptosis, as measured histochemically, and upregulated PARP1, a DNA damage repair enzyme. These results are the first to show that lidocaine induces apoptosis through ER stress in vitro and in vivo.

ISSN 

1422-0067

Link 

http://dx.doi.org/10.3390/ijms12117652

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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