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Title 

The N-end rule pathway: emerging functions and molecular principles of substrate recognition

Authors 

S M SriramBo Yeon KimY T Kwon

Publisher 

Nature Publishing Group

Issue Date 

2011

Citation 

Nature Reviews Molecular Cell Biology, vol. 12, no. 12, pp. 735-747

Abstract 

The N-end rule defines the protein-destabilizing activity of a given amino-terminal residue and its post-translational modification. Since its discovery 25 years ago, the pathway involved in the N-end rule has been thought to target only a limited set of specific substrates of the ubiquitin-proteasome system. Recent studies have provided insights into the components, substrates, functions and structural basis of substrate recognition. The N-end rule pathway is now emerging as a major cellular proteolytic system, in which the majority of proteins are born with or acquire specific N-terminal degradation determinants through protein-specific or global post-translational modifications.

ISSN 

1471-0072

Link 

http://dx.doi.org/10.1038/nrm3217

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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