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Title 

Flavonoids biotransformation by bacterial non-heme dioxygenases, biphenyl and naphthalene dioxygenase

Authors 

Ji-Young SeoS I KangM KimJ HanH G Hur

Publisher 

Springer Verlag (Germany)

Issue Date 

2011

Citation 

Applied Microbiology and Biotechnology, vol. 91, no. 2, pp. 219-228

Keywords 

BiotransformationBiphenyl dioxygenaseFlavonoidNaphthalene dioxygenasePolyphenol

Abstract 

This review details recent progresses in the flavonoid biotransformation by bacterial non-heme dioxygenases, biphenyl dioxygenase (BDO), and naphthalene dioxygenase (NDO), which can initially activate biphenyl and naphthalene with insertion of dioxygen in stereospecfic and regiospecific manners. Flavone, isoflavone, flavanone, and isoflavanol were biotransformed by BDO from Pseudomonas pseudoalcaligenes KF707 and NDO from Pseudomonas sp. strain NCIB9816-4, respectively. In general, BDO showed wide range of substrate spectrum and produced the oxidized products, whereas NDO only metabolized flat two-dimensional substrates of flavone and isoflavone. Furthermore, biotransformation of B-ring skewed substrates, flavanone and isoflavanol, by BDO produced the epoxide products, instead of dihydrodiols. These results support the idea that substrate-driven reactivity alteration of the Fe-oxo active species may occur in the active site of non-heme dioxygenases. The study of flavonoid biotransformation by structurally-well defined BDO and NDO will provide the substrate structure and reactivity relationships and eventually establish the production of non-plant-originated flavonoids by means of microbial biotechnology.

ISSN 

0175-7598

Link 

http://dx.doi.org/10.1007/s00253-011-3334-z

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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