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Title 

Butamben derivatives enhance BMP-2-stimulated commitment of C2C12 cells into osteoblasts with induction of voltage-gated potassium channel expression

 

부탐벤의 골형성 효과

Authors 

H J KimM ParkY M HanByoung-Mog KwonS H Kim

Publisher 

Elsevier

Issue Date 

2011

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 21, no. 24, pp. 7363-7366

Keywords 

Bone morphogenetic proteinButambenDrug repositioningOsteoblastogenesisVoltage-gated potassium channel

Abstract 

As the primary step for 'drug repositioning', we evaluated the effect of 2000 drugs and drug candidates on the commitment of bi-potential mesenchymal precursor C2C12 cells into osteoblasts in the presence of bone morphogenetic protein (BMP)-2 and found that butamben enhanced BMP-2-stimulated induction of alkaline phosphatase, a biomarker of osteoblastogenesis. Investigating the underlying mechanism of its anabolic actions, we found anabolic action of its derivative (compound 4) relies on BMP-2 signaling and mRNA induction of BMPs and voltage-gated potassium channels.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2011.10.020

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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