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Title 

Human Acyl-CoA:cholesterol acyltransferase (hACAT)-inhibiting triterpenes from Lythrum salicaria L.

Authors 

G S KimS E LeeTae Sook JeongC G ParkJ S SungJ B KimY P HongY C KimK S Song

Publisher 

Korean Society for Applied Biological Chemisty

Issue Date 

2011

Citation 

Journal of Korean Society for Applied Biological Chemistry, vol. 54, no. 4, pp. 628-632

Abstract 

β-Sitosterol (1), betulinic acid (2), and 3β-hydroxy-20(29)-lupen-28-oic acid methyl ester (3) were isolated from the herbal parts of Lythrum salicaria. Compounds 2 and 3 were isolated for the first time from L. salicaria and they showed inhibitory activities on both hACAT1 and hACAT2. These results suggested that L. salicaria, which contains triterpenes 2 and 3, might be effective in the prevention and treatment of hypercholesterolemia or atherosclerosis due to its inhibitory effect on hACAT.

ISSN 

1738-2203

Link 

http://dx.doi.org/10.3839/jksabc.2011.095

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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