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Title 

Cug2 is essential for normal mitotic control and CNS develpment in zebrafish

 

제브라피쉬의 중추신경계 발생과 정상적 유사분열 조절에 필수 인자인 Cug2

Authors 

H T KimJ H SoS H JungD G AhnW KohNam-Soon KimS H KimS LeeC H Kim

Publisher 

BioMed Central

Issue Date 

2011

Citation 

BMC Developmental Biology, vol. 11, no. 0, pp. 49-49

Abstract 

Background: We recently identified a novel oncogene, Cancer-upregulated gene 2 (CUG2), which is essential for kinetochore formation and promotes tumorigenesis in mammalian cells. However, the in vivo function of CUG2 has not been studied in animal models. Results: To study the function of CUG2 in vivo, we isolated a zebrafish homologue that is expressed specifically in the proliferating cells of the central nervous system (CNS). Morpholino-mediated knockdown of cug2 resulted in apoptosis throughout the CNS and the development of neurodegenerative phenotypes. In addition, cug2-deficient embryos contained mitotically arrested cells displaying abnormal spindle formation and chromosome misalignment in the neural plate. Conclusions: Therefore, our findings suggest that Cug2 is required for normal mitosis during early neurogenesis and has functions in neuronal cell maintenance, thus demonstrating that the cug2 deficient embryos may provide a model system for human neurodegenerative disorders.

ISSN 

1471-213X

Link 

http://dx.doi.org/10.1186/1471-213X-11-49

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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