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Title 

RPTPu tyrosine phopshatase promotes adipogenic differentiation via modultion of p120 catenin phosphoryltion

Authors 

Won Kon-KimHyeyun JungEun Young KimDo Hyung KimYee Sook ChoByoung Chul ParkSung Goo ParkY KoKwang-Hee BaeSang Chul Lee

Publisher 

American Society for Cell Biology

Issue Date 

2011

Citation 

Molecular Biology of the Cell, vol. 22, no. 24, pp. 4883-4891

Abstract 

Adipocyte differentiation can be regulated by the combined activity of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). In particular, PTPs act as key regulators in differentiation-associated signaling pathways. We recently found that receptor-type PTPμ (RPTPμ) expression is markedly increased during the adipogenic differentiation of 3T3-L1 preadipocytes and mesenchymal stem cells. Here, we investigate the functional roles of RPTPμ and the mechanism of its involvement in the regulation of signal transduction during adipogenesis of 3T3-L1 cells. Depletion of endogenous RPTPμ by RNA interference significantly inhibited adipogenic differentiation, whereas RPTPμ overexpression led to an increase in adipogenic differentiation. Ectopic expression of p120 catenin suppressed adipocyte differentiation, and the decrease in adipogenesis by p120 catenin was recovered by introducing RPTPμ. Moreover, RPTPμ induced a decrease in the cytoplasmic p120 catenin expression by reducing its tyrosine phosphorylation level, consequently leading to enhanced translocation of Glut-4 to the plasma membrane. On the basis of these results, we propose that RPTPμ acts as a positive regulator of adipogenesis by modulating the cytoplasmic p120 catenin level. Our data conclusively demonstrate that differentiation into adipocytes is controlled by RPTPμ, supporting the utility of RPTPμ and p120 catenin as novel target proteins for the treatment of obesity.

ISSN 

1059-1524

Link 

http://dx.doi.org/10.1091/mbc.E11-03-0175

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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