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Title 

A combination of grape extract, green tea extract and l -carnitine improves high-fat diet-induced obesity, hyperlipidemia and non-alcoholic fatty liver disease in mice

Authors 

Jong Soon KangW K LeeWoon Kee YoonN KimS K ParkH K ParkS Y LyS B HanJi Eun YunChang Woo LeeK LeeKi Hoon LeeHwan Mook Kim

Publisher 

Wiley-Blackwell

Issue Date 

2011

Citation 

Phytotherapy Research, vol. 25, no. 12, pp. 1789-1795

Keywords 

fatty liver diseasegrape extractgreen tea extracthigh-fat diethyperlipidemial -carnitine

Abstract 

To develop a therapeutic agent for obesity-related metabolic disorders, a mixture of dietary components was prepared, including grape extract, green tea extract and l-carnitine (RGTC), and its effects on obesity, hyperlipidemia and non-alcoholic fatty liver disease examined. The RGTC dramatically inhibited the high-fat diet (HFD)-induced increase in body weight and fat in C57BL/6 mice, whereas food consumption was not affected by RGTC treatment. The RGTC also concentration-dependently suppressed the HFD-induced increase in plasma lipids, such as low-density lipoprotein cholesterol and triglycerides. In addition, increases in liver weight and liver steatosis were returned to normal by RGTC treatment in HFD-fed C57BL/6 mice. The plasma levels of glutamic-oxaloacetic transaminase and glutamic-pyruvic transaminase were also significantly down-regulated by RGTC treatment. These results suggest that RGTC suppressed HFD-induced obesity, hyperlipidemia and non-alcoholic fatty liver disease, suggesting that RGTC supplementation might be a promising adjuvant therapy for the treatment of these metabolic disorders.

ISSN 

0951-418X

Link 

http://dx.doi.org/10.1002/ptr.3476

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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