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Title 

Bioderived polyelectrolyte nanogels for robust antigen loading and vaccine adjuvant effects

Authors 

Y T LimSang-Moo ShimY W NohK S LeeD Y ChoiH UyamaH H BaeJ H KimK S HongM H SungHaryoung Poo

Publisher 

Wiley-Blackwell

Issue Date 

2011

Citation 

Small, vol. 7, no. 23, pp. 3281-3286

Keywords 

antigensdendritic cellsdrug deliverypolyelectrolyte nanogelsvaccine adjuvant

Abstract 

An easy but robust strategy for the synthesis of bioderived polyelectrolyte nanogels for protein antigen loading and vaccine adjuvant systems that can improve both humoral (Th2) and cellular immunity (Th1) is presented. The synthesized polyelectrolyte nanogels promote the uptake of antigens into antigen-presenting cells and strongly induce ovalbumin-specific INF-γ producing cells, cytotoxic T cell activity, and antibody production.

ISSN 

1613-6810

Link 

http://dx.doi.org/10.1002/smll.201101836

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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