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Title 

Two-temperature hybridization for microarray detection of label-free microRNAs with attomole detection and superior specificity

 

두 가지 온도를 이용한 마이크로 RNA 어레이 분석

Authors 

Jeong Min LeeYongwon Jung

Publisher 

Wiley-Blackwell

Issue Date 

2011

Citation 

Angewandte Chemie International Edition, vol. 50, no. 52, pp. 12487-12490

Keywords 

biosensorsLNAsmicroarraysmicroRNAsRNA recognition

Abstract 

Two is better than one: Two short locked nucleic acid based probes were used to collectively capture and detect microRNAs by a simple two-temperature hybridization process. Intact microRNAs were directly measured down to attomolar concentrations with a high specificity and nearly four orders of magnitude of dynamic range. Single base mismatches in the microRNAs were potently discriminated from the perfectly matched targets.

ISSN 

1433-7851

Link 

http://dx.doi.org/10.1002/anie.201105605

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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