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Title 

Emodin inhibits migration and invasion of DLD-1 (PRL-3) cells via inhibition of PRL-3 phosphatase activity

 

Emodin의 암세포 이동저해 효과

Authors 

Young Min HanS K LeeDae Gwin JeongS E RyuDong Cho HanD K KimByoung-Mog Kwon

Publisher 

Elsevier

Issue Date 

2012

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 22, no. 1, pp. 323-326

Keywords 

EmodinInvasionMetastasisMigrationPRL-3

Abstract 

Anthraquinones have been reported as phosphatase inhibitors. Therefore, anthraquinone derivatives were screened to identify a potent phosphatase inhibitor against the phosphatase of regenerating liver-3 (PRL-3). Emodin strongly inhibited phosphatase activity of PRL-3 with IC 50 values of 3.5 μM and blocked PRL-3-induced tumor cell migration and invasion in a dose-dependent manner. Emodin rescued the phosphorylation of ezrin, which is a known PRL-3 substrate. The results of this study reveal that emodin is a PRL-3 inhibitor and a good lead molecule for obtaining a selective PRL-3 inhibitor.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2011.11.008

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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