상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Genome-wide identification of chemosensitive single nucleotide polymorphism markers in gastric cancer

Authors 

Y J HaS N YoonY J JeonD H ChoS A RohB S KimHee Jin KimSeon-Young KimYong Sung KimJ C Kim

Publisher 

International Institute of Anticancer Research (IIAR)

Issue Date 

2011

Citation 

Anticancer Research, vol. 31, no. 12, pp. 4329-4338

Keywords 

ChemosensitivityDNASE2BDocetaxelGastric cancer (GC)HTRIESingle nucleotide polymorphisms (SNPs)

Abstract 

A chemosensitive single nucleotide polymorphism (SNP) discovery schema is presented that utilizes (i) genomewide SNP screening, with a human SNP array and an in vitro chemosensitivity assay, in 93 patients with gastric cancer(GC), and (ii) biological utility assessment using cell viability assays of transfected GC cells. Cytotoxicity analysis showed that most of the MKN1 and SNU638 clones transfected with the G allele of Deoxyribonuclease II beta (DNASE2B) rs3738573 were more sensitive to docetaxel than those with the C allele (p≤0.001-0.029) and most of the AGS and SNU638 clones transfected with the T allele of 5-hydroxytryptamine receptor IE (HTRIE) rs3828741 were more sensitive to paclitaxel than those with the C allele (p≤0.001-0.019). Our findings show that the two novel markers, DNASE2B rs3738573 and HTR1E rs3828741, have potential for improving the prediction of chemosensitivity of GC patients.

ISSN 

0250-7005

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)