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Title 

Immunostimulatory effect by aqueous extract of Hizikia fusiforme in RAW 264.7 macrophage and whole spleen cells

Authors 

Yeo Dae YoonE S LeeJ P ParkM R KimJ W LeeT H KimM K NaJ H Kim

Publisher 

Springer Verlag (Germany)

Issue Date 

2011

Citation 

Biotechnology and Bioprocess Engineering, vol. 16, no. 6, pp. 1099-1105

Keywords 

Hizikia fusiformeImmunostimulatory activityNitric oxideRAW 264.7 macrophageSpleen cells

Abstract 

Hizikia fusiforme is a commonly used food that possesses potent anti-bacterial, anti-fungal, and antiinflammatory activities. The immunostimulatory activities of aqueous extract of Hizikia fusiforme (HFAE) in RAW 264.7 macrophages and whole spleen cells were investigated. HFAE activated RAW 264.7 macrophages to produce cytokines such as nitric oxide (NO), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) in a dose-dependent manner. In addition, HFAE induced the mRNA expression of TNF-α, IL-1β, and IL-6 in RAW 264.7 macrophages. Moreover, HFAE stimulated proliferation of whole spleen cells and reference mitogen. Taken together, the results demonstrate that HFAE potently activates the immune function by regulating NO, TNF-α, IL-1β, and IL-6 in RAW 264.7 macrophage and promoting spleen cell proliferation.

ISSN 

1226-8372

Link 

http://dx.doi.org/10.1007/s12257-011-0177-5

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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