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Title 

Identification of proteins differentially expressed in gastric cancer cells with high metastatic potential for invasion to lymph nodes

Authors 

D H LeeYoura LeeJoohyun RyuSung Goo ParkS ChoJ J LeeC ChoiByoung Chul Park

Publisher 

Springer Verlag (Germany)

Issue Date 

2011

Citation 

Molecules and Cells, vol. 31, no. 6, pp. 563-571

Keywords 

AATAGR2DBPgastric cancermetastasisproteome

Abstract 

In a search for proteins involved in cancer metastasis, we analyzed proteomes of the human gastric cancer cell OCUM-2M and its metastatic subline OCUM-2MLN. We observed that aspartate aminotransferase (AAT), D-site binding protein (DBP), and anterior gradient protein 2 (AGR2) are differentially expressed in metastatic OCUM-2MLN cells. Measurement of protein expression in clinical samples indicated that DBP and AAT are also down-regulated in metastatic adenocarcinoma. Additionally, urokinase-type tissue plasminogen activator is up-regulated in OCUM-2MLN cells and also in metastatic gastric cancer samples. Collectively, these results raise a possibility that AAT, DBP and AGR2 are functionally implicated in the invasiveness of gastric cancer cells.

ISSN 

1016-8478

Link 

http://dx.doi.org/10.1007/s10059-011-1053-z

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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