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Title | Isolation of diacyl glycerol acyl transferase (DGAT) inhibitors from Pachydictyon coriaceum |
Authors | B W Choi; Hyun Sun Lee; K B Lee; B H Lee |
Publisher | Wiley-Blackwell |
Issue Date | 2011 |
Citation | Phytotherapy Research, vol. 25, no. 7, pp. 1041-1045 |
Keywords | Acyl CoA:diacylglycerol acyltransferase (DGAT); Hypertriglyceridemia; Obesity; Pachydictyon coriaceum; Terpenoids; Type 2 diabetes |
Abstract | The pharmacological inhibition of acyl CoA:diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) has emerged as a target for the treatment of obesity and type 2 diabetes. Chromatographic analysis of the brown alga, Pachydictyon coriaceum, led to the isolation of diterpene dictyol E and hydroxyisocrenulatin. Pharmacological assay of these compounds demonstrated DGAT inhibitory activity with IC50 values of 46.0 μM and 23.3 μM, respectively. |
ISSN | 0951-418X |
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Registered Date |
2017-04-19 |
