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Title 

Isolation of diacyl glycerol acyl transferase (DGAT) inhibitors from Pachydictyon coriaceum

Authors 

B W ChoiHyun Sun LeeK B LeeB H Lee

Publisher 

Wiley-Blackwell

Issue Date 

2011

Citation 

Phytotherapy Research, vol. 25, no. 7, pp. 1041-1045

Keywords 

Acyl CoA:diacylglycerol acyltransferase (DGAT)HypertriglyceridemiaObesityPachydictyon coriaceumTerpenoidsType 2 diabetes

Abstract 

The pharmacological inhibition of acyl CoA:diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) has emerged as a target for the treatment of obesity and type 2 diabetes. Chromatographic analysis of the brown alga, Pachydictyon coriaceum, led to the isolation of diterpene dictyol E and hydroxyisocrenulatin. Pharmacological assay of these compounds demonstrated DGAT inhibitory activity with IC50 values of 46.0 μM and 23.3 μM, respectively.

ISSN 

0951-418X

Link 

http://dx.doi.org/10.1002/ptr.3391

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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