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Title 

Tiarellic acid attenuates airway hyperresponsiveness and inflammation in a murine model of allergic asthma

Authors 

M Y LeeKyung Seop AhnH S LimJ E YukOk-Kyoung KwonK Y LeeHyeong Kyu LeeSei Ryang Oh

Publisher 

Elsevier

Issue Date 

2012

Citation 

International Immunopharmacology, vol. 12, no. 1, pp. 117-124

Keywords 

AsthmaCytokineReactive oxygen speciesTiarellic acid

Abstract 

Asthma is a persistent inflammatory disease characterized by airway obstruction and hyperresponsiveness in association with airway inflammation. In the current research, we studied the anti-inflammatory and anti-asthmatic effects of tiarellic acid (TA) isolated from Tiarella polyphylla, based on asthmatic parameters, such as immunoglobulin E (IgE) level, cytokine release, eosinophilia, airway hyperresponsiveness (AHR), reactive oxygen species (ROS) and mucus hypersecretion, in an ovalbumin (OVA)-sensitized/challenged mouse model. TA significantly inhibited increases in IgE, levels of ROS and T helper cytokines, such as interleukin (IL)-4, IL-5, TNF-α, and IL-13, in bronchoalveolar lavage fluid (BALF), and effectively suppressed airway hyperresponsiveness, eosinophilia, and mucus hypersecretion in the asthmatic mouse model. In addition, we found that administration of TA attenuated ovalbumin-induced increases in NF-κB activity in lungs. The efficacy of TA was comparable to that of montelukast, a currently available anti-asthmatic drug. Our results support the utility of TA as a herbal medicine for asthma treatment and may have application in the development of anti-inflammatory and anti-asthmatic drugs.

ISSN 

1567-5769

Link 

http://dx.doi.org/10.1016/j.intimp.2011.10.021

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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